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GENERAL
TITLE
CRYSTAL STRUCTURE OF DOT1L IN COMPLEX WITH EPZ003696
DATE LAST MODIFIED
Sep 13, 2023
RELEASE
Oct 17, 2012
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 65
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
41.7
PUBMED ID
DOI
10.1111/CBDD.12050
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q8TEK3 DOT1L, KIAA1814, KMT4 ESCHERICHIA COLI HUMAN
DOT1-LIKE PROTEIN, HISTONE H3-K79 METHYLTRANSFERAS ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402