5HG8

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 5HG8_A

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GENERAL

TITLE

EGFR (L858R, T790M, V948R) IN COMPLEX WITH N-[3-({2-[(1-METHYL-1H- PYRAZOL-4-YL)AMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL}OXY)PHENYL]PROP- 2-ENAMIDE

DATE LAST MODIFIED

Nov 22, 2017

RELEASE

Feb 3, 2016

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

1.42

RESOLUTION RANGE LOW

58.99

PUBMED ID

DOI

10.1021/ACS.JMEDCHEM.5B01633

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	P00533	EGFR, ERBB, ERBB1, HER1	SPODOPTERA FRUGIPERDA	HUMAN	PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402