5PGV

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Bioassembly 5PGV_1

Bioassembly 5PGV_2

Chain 5PGV_A

Chain 5PGV_B

Chain 5PGV_D

Chain 5PGV_E

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GENERAL

TITLE

CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 1-(3-HYDROXYAZETIDIN-1-YL)-2-[(2S,5R)-2-(4- FLUOROPHENYL)-5-METHOXYADAMANTAN-2-YL]ETHAN-1-ONE

DATE LAST MODIFIED

Feb 21, 2018

RELEASE

Nov 1, 2017

CLASSIFICATION

OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

2.35

RESOLUTION RANGE LOW

PUBMED ID

28537398

DOI

10.1021/ACS.JMEDCHEM.7B00211

PDBe

LIGANDS

2842878 , 931316

Chains

Target Protein	Gene	Expression System	Organism	Synonims	Actions
P28845	HSD11B1, HSD11, HSD11L, SDR26C1	ESCHERICHIA COLI	HUMAN	11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...	Mutations
P28845	HSD11B1, HSD11, HSD11L, SDR26C1	ESCHERICHIA COLI	HUMAN	11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...	Mutations
P28845	HSD11B1, HSD11, HSD11L, SDR26C1	ESCHERICHIA COLI	HUMAN	11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...	Mutations
P28845	HSD11B1, HSD11, HSD11L, SDR26C1	ESCHERICHIA COLI	HUMAN	11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-BETA-HSD ...	Mutations

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402