FEATURES

FAMILY

DESCRIPTION

Also known as KITM_HUMAN, TK2. Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:9989599, PubMed:11687801). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (PubMed:9989599). Widely used as target of antiviral and chemotherapeutic agents (PubMed:9989599). Monomer.

Also known as KITM_HUMAN, TK2. Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:9989599, PubMed:11687801). In non-replicating cells, where cytosolic d ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TK2

Thymidine kinase 2, mitochondrial

TK2

Molecular Synopsis