FEATURES

FAMILY

DESCRIPTION

Also known as CDC7_HUMAN, CDC7, CDC7L1. Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity (PubMed:10373557, PubMed:12065429, PubMed:15668232, PubMed:17062569). Interacts with CLASPIN (via the acidic patch); the interaction is required for phosphorylation of MCM proteins and CLASPIN (PubMed:27401717).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDC7

Cell division cycle 7-related protein kinase

CDC7

Molecular Synopsis