FEATURES

FAMILY

DESCRIPTION

Also known as CTRO_HUMAN, CIT, CRIK, KIAA0949, STK21. Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CIT

Citron Rho-interacting kinase

CIT

Molecular Synopsis