FEATURES

FAMILY

DESCRIPTION

Also known as P4HA2_HUMAN, P4HA2. Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Heterotetramer of two alpha-2 chains and two beta chains (P4HB) (the beta chain is the multi-functional PDI), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

P4HA2

Prolyl 4-hydroxylase subunit alpha-2

P4HA2

Molecular Synopsis