FEATURES

FAMILY

DESCRIPTION

Also known as OGG1_HUMAN, OGG1, MMH, MUTM, OGH1. DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7, 8-dihydro-8-oxoguanine and 2, 6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

OGG1

N-glycosylase/DNA lyase

OGG1

Molecular Synopsis