FEATURES

FAMILY

DESCRIPTION

Also known as GGCT_HUMAN, GGCT, C7orf24, CRF21. Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GGCT

Gamma-glutamylcyclotransferase

GGCT

Molecular Synopsis