FEATURES

FAMILY

mitochondrial carrier (TC 2.A.29) family

DESCRIPTION

Also known as S2512_HUMAN, SLC25A12, AGC1, ARALAR1. Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Homodimer (via N-terminus).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC25A12

Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

SLC25A12

Molecular Synopsis