FEATURES

FAMILY

isocitrate and isopropylmalate dehydrogenases family

DESCRIPTION

Also known as IDHC_HUMAN, IDH1, PICD. Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IDH1

Isocitrate dehydrogenase [NADP] cytoplasmic

IDH1

Molecular Synopsis