FEATURES

FAMILY

DESCRIPTION

Also known as KDM4B_HUMAN, KDM4B, JHDM3B, JMJD2B, KIAA0876. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS).

Also known as KDM4B_HUMAN, KDM4B, JHDM3B, JMJD2B, KIAA0876. Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KDM4B

Lysine-specific demethylase 4B

KDM4B

Molecular Synopsis