FEATURES

FAMILY

calcium channel alpha-1 subunit (TC 1.A.1.11) family

DESCRIPTION

Also known as CAC1H_HUMAN, CACNA1H. Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). Interacts (via N-terminal cytoplasmic domain) with STAC.

EXTERNAL LINKS

CACNA1H

Voltage-dependent T-type calcium channel subunit alpha-1H

CACNA1H

Molecular Synopsis