FEATURES

FAMILY

DESCRIPTION

Also known as DYR_HUMAN, DHFR. Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DHFR

Dihydrofolate reductase

DHFR

Molecular Synopsis