FEATURES

FAMILY

DESCRIPTION

Also known as ANT3_HUMAN, SERPINC1, AT3. Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, PubMed:15140129). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin. Forms protease inhibiting heterodimer with TMPRSS7.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SERPINC1

Antithrombin-III

SERPINC1

Molecular Synopsis