FEATURES

FAMILY

DESCRIPTION

Also known as CO2_HUMAN, C2. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

C2

Complement C2

C2

Molecular Synopsis