FEATURES

DESCRIPTION

Also known as CD2_HUMAN, CD2, SRBC. CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (PubMed:10380930). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (PubMed:9857189). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CD2

T-cell surface antigen CD2

CD2

Molecular Synopsis