FEATURES

FAMILY

DESCRIPTION

Also known as CAN1_HUMAN, CAPN1, CANPL1. Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). Forms a heterodimer with a small (regulatory) subunit CAPNS1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CAPN1

Calpain-1 catalytic subunit

CAPN1

Molecular Synopsis