FEATURES

FAMILY

DESCRIPTION

Also known as SRPRA_HUMAN, SRPRA, SRPR. Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Heterodimer with SRPRB (PubMed:16439358). Interacts with the signal recognition particle (SRP) complex subunit SRP54 (PubMed:34020957).

EXTERNAL LINKS

SRPRA

Signal recognition particle receptor subunit alpha

SRPRA

Molecular Synopsis