FEATURES

FAMILY

DESCRIPTION

Also known as ADRB1_HUMAN, ADRB1, ADRB1R, B1AR. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed:31473062). Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADRB1

Beta-1 adrenergic receptor

ADRB1

Molecular Synopsis