FEATURES

DESCRIPTION

Also known as PYC_HUMAN, PC. Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. Homotetramer (PubMed:18297087). Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PC

Pyruvate carboxylase, mitochondrial

PC

Molecular Synopsis