FEATURES

FAMILY

DESCRIPTION

Also known as IMDH2_HUMAN, IMPDH2, IMPD2. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7903306, PubMed:7763314). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors. Homotetramer (PubMed:7903306, Ref.28, Ref.29). Interacts with CLOCK; in a circadian manner (PubMed:28985504). Interacts with ANKRD9; leading to its ubiquitination and degradation by the proteasome (PubMed:30293565).

EXTERNAL LINKS

IMPDH2

Inosine-5'-monophosphate dehydrogenase 2

IMPDH2

Molecular Synopsis