FEATURES

FAMILY

DESCRIPTION

Also known as FCGR1_HUMAN, FCGR1A, FCG1, FCGR1, IGFR1. High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. Interacts with IGHG1 (PubMed:11711607). Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FCGR1A

High affinity immunoglobulin gamma Fc receptor I

FCGR1A

Molecular Synopsis