FEATURES

FAMILY

DESCRIPTION

Also known as P4HA1_HUMAN, P4HA1, P4HA. Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Heterotetramer of two alpha-1 chains and two beta chains (P4HB)(the beta chain is the multi-functional PDI), where P4HB plays the role of a structural subunit; this tetramer catalyzes the formation of 4-hydroxyproline in collagen.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

P4HA1

Prolyl 4-hydroxylase subunit alpha-1

P4HA1

Molecular Synopsis