FEATURES

DESCRIPTION

Also known as LFA3_HUMAN, CD58, LFA3. Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Interacts with CD2 (PubMed:10380930, PubMed:3309127). Interacts with CMTM6 (PubMed:28813417).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CD58

Lymphocyte function-associated antigen 3

CD58

Molecular Synopsis