FEATURES

FAMILY

class-V pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as AGT1_HUMAN, AGXT, AGT1, SPAT. Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:24055001, PubMed:23229545, PubMed:26149463). Also catalyzes the transamination between L-serine and pyruvate and contributes to gluconeogenesis from the L-serine metabolism (PubMed:10347152). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AGXT

Alanine--glyoxylate aminotransferase

AGXT

Molecular Synopsis