FEATURES

FAMILY

DESCRIPTION

Also known as CCNE1_HUMAN, CCNE1, CCNE. Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CCNE1

G1/S-specific cyclin-E1

CCNE1

Molecular Synopsis