FEATURES

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

DESCRIPTION

Also known as GUC2C_HUMAN, GUCY2C, GUC2C, STAR. Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:1718270, PubMed:11950846, PubMed:23269669, PubMed:22521417, PubMed:22436048). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1718270, PubMed:1680854). Also activated by the endogenous peptides guanylin and uroguanylin (PubMed:8381596). Homotrimer (PubMed:11123935). Interacts via its C-terminal region with PDZK2 (PubMed:11950846). Interacts with the lectin chaperone VIP36 (PubMed:23269669).

Also known as GUC2C_HUMAN, GUCY2C, GUC2C, STAR. Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:1718270, PubMed:11950846, PubMed:23269669, PubMed:22521417, PubMe ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GUCY2C

Guanylyl cyclase C

GUCY2C

Molecular Synopsis