FEATURES

FAMILY

DESCRIPTION

Also known as CDC50_YEAST, CDC50, SWA4. Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylserine and small amounts of ethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:16956384, PubMed:22791719, PubMed:28302728, PubMed:31243363, PubMed:31515475, PubMed:34023399, PubMed:25393116, PubMed:19411703). Required for the formation of transport vesicles from endosomes (PubMed:21212072). Component of a flippase complex consisting of DRS2 and CDC50 (PubMed:19411703, PubMed:22791719, PubMed:25393116, PubMed:28302728, PubMed:31243363, PubMed:31515475, PubMed:34023399, Ref.17). Interacts with DRS2; the interaction is direct, is required for their mutual export from the endoplasmic reticulum, and preferentially occurs when DRS2 is in the E2P state (PubMed:15090616, PubMed:16956384, PubMed:19411703, PubMed:21212072, PubMed:22791719, PubMed:25393116, PubMed:28302728, PubMed:31243363, PubMed:31515475, PubMed:34023399, Ref.17).

EXTERNAL LINKS

CDC50

Mutations

Mutation(s) distribution

Mutations table