FEATURES

FAMILY

class-II aminoacyl-tRNA synthetase family

DESCRIPTION

Also known as SYTC_HUMAN, TARS1, TARS. Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TARS1

Threonine--tRNA ligase 1, cytoplasmic

TARS1

Molecular Synopsis