FEATURES

FAMILY

DESCRIPTION

Also known as CCN2_HUMAN, CCN2, CTGF, HCS24, IGFBP8. Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Monomer (PubMed:1654338). Interacts with TSKU (PubMed:30232710).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CCN2

CCN family member 2

CCN2

Molecular Synopsis