FEATURES

FAMILY

ribonucleoside diphosphate reductase small chain family

DESCRIPTION

Also known as RIR2_HUMAN, RRM2, RR2. Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Heterodimer of a large and a small subunit. Interacts (via Cy motif and when phosphorylated at Thr-33) with CCNF; the interaction occurs exclusively in G2 and early M (PubMed:22632967).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RRM2

Ribonucleoside-diphosphate reductase subunit M2

RRM2

Molecular Synopsis