FEATURES

FAMILY

cytidine and deoxycytidylate deaminase family

DESCRIPTION

Also known as ABC3A_HUMAN, APOBEC3A. DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Interacts with AGO2. Interacts with TRIB3 (via N-terminus).

EXTERNAL LINKS

APOBEC3A

DNA dC->dU-editing enzyme APOBEC-3A

APOBEC3A

Molecular Synopsis