FEATURES

FAMILY

DESCRIPTION

Also known as UBP6_HUMAN, USP6, HRP1, TRE2. Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. Interacts with RAC1 and CDC42. Interacts (via Rab-GAP TBC domain) with ARF6. Interacts with calmodulin (CALM1, CALM2 and/or CALM3); the interaction is calcium-dependent.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

USP6

Ubiquitin carboxyl-terminal hydrolase 6

USP6

Molecular Synopsis