FEATURES

DESCRIPTION

Also known as SOX18_HUMAN, SOX18. Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. Interacts (via C-terminus) with MEF2C (via MADS box).

EXTERNAL LINKS

SOX18

Transcription factor SOX-18

SOX18

Molecular Synopsis