FEATURES

FAMILY

DESCRIPTION

Also known as K22E_HUMAN, KRT2, KRT2A, KRT2E. Probably contributes to terminal cornification (PubMed:1380918). Associated with keratinocyte activation, proliferation and keratinization (PubMed:12598329). Required for maintenance of corneocytes and keratin filaments in suprabasal keratinocytes in the epidermis of the ear, potentially via moderation of expression and localization of keratins and their partner proteins (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Heterotetramer of two type I and two type II keratins. Associates with KRT10.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KRT2

Keratin, type II cytoskeletal 2 epidermal

KRT2

Molecular Synopsis