FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE6B_HUMAN, PDE6B, PDEB. Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3', 5'-cyclic GMP (PubMed:20940301). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (PubMed:8394174). Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDE6B

Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta

PDE6B

Molecular Synopsis