FEATURES

FAMILY

cation transport ATPase (P-type) (TC 3.A.3) family

DESCRIPTION

Also known as ATC3_YEAST, DRS2, SWA3. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylserine and small amounts of ethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:15249668, PubMed:16452632, PubMed:16956384, PubMed:19411703, PubMed:19898464, PubMed:19805341, PubMed:22308393, PubMed:24045945, PubMed:25393116, PubMed:28302728, PubMed:30824614, PubMed:31243363, PubMed:31515475, PubMed:34023399). Contributes to clathrin-coated vesicle formation, endocytosis, and protein trafficking between the Golgi and endosomal system (PubMed:15249668, PubMed:12372257, PubMed:10601336, PubMed:8247005, PubMed:16452632, PubMed:16956384, PubMed:21212072). Does not appear to transport phosphatidylcholine or sphingomyelin (PubMed:19805341, PubMed:24045945, PubMed:15249668). Component of a flippase complex consisting of DRS2 and CDC50 (PubMed:19411703, PubMed:22791719, PubMed:25393116, PubMed:28302728, PubMed:31243363, PubMed:31515475, Ref.33). Interacts with CDC50; the interaction is direct, is required for their mutual export from the endoplasmic reticulum, and preferentially occurs when DRS2 is in the E2P state (PubMed:15090616, PubMed:16956384, PubMed:19411703, PubMed:21212072, PubMed:22791719, PubMed:25393116, PubMed:28302728, PubMed:31243363, PubMed:31515475, Ref.33). Interacts (via C-terminus) with GEA2 (via SEC7 domain); the interaction is direct (PubMed:14734650). Interacts with GEA1 (PubMed:14734650).

EXTERNAL LINKS

DRS2

Mutations

Mutation(s) distribution

Mutations table