FEATURES

FAMILY

CDKN2 cyclin-dependent kinase inhibitor family

DESCRIPTION

Also known as CDN2A_HUMAN, CDKN2A, CDKN2, MTS1. Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDKN2A

Cyclin-dependent kinase inhibitor 2A

CDKN2A

Molecular Synopsis