FEATURES

FAMILY

DESCRIPTION

Also known as T23O_HUMAN, TDO2, TDO. Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Homotetramer. Dimer of dimers.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TDO2

Tryptophan 2, 3-dioxygenase

TDO2

Molecular Synopsis