FEATURES

DESCRIPTION

Also known as RGS19_HUMAN, RGS19, GAIP, GNAI3IP. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. Interacts with GIPC PDZ domain. Interacts with GNAO1 (PubMed:34685729).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RGS19

Regulator of G-protein signaling 19

RGS19

Molecular Synopsis