FEATURES

FAMILY

DESCRIPTION

Also known as GDIB_HUMAN, GDI2, RABGDIB. GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). Interacts with RHOH (PubMed:11809807). Interacts with the GDP-bound forms of RAB3A, RAB3B, RAB3C, RAB5A, RAB5B, RAB5C, RAB8B, RAB10, RAB12, RAB35, and RAB43; binds RAB3D to a lesser extent (PubMed:26824392, PubMed:29125462). Interacts with RAB8A (GDP-bound inactive form); prevents RAB8A activation (PubMed:25860027, PubMed:26824392, PubMed:29125462). Interacts with DZIP1; negatively regulates the interaction of GDI2 with GDP-bound RAB8A (PubMed:25860027).

EXTERNAL LINKS

GDI2

Rab GDP dissociation inhibitor beta

GDI2

Molecular Synopsis