FEATURES

FAMILY

amiloride-sensitive sodium channel (TC 1.A.6) family

DESCRIPTION

Also known as SCNND_HUMAN, SCNN1D, DNACH. Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotrimer containing a delta/SCNN1D, a beta/SCNN1B and a gamma/SCNN1G subunit. The additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SCNN1D

Amiloride-sensitive sodium channel subunit delta

SCNN1D

Molecular Synopsis