FEATURES

FAMILY

DESCRIPTION

Also known as GPM6A_HUMAN, GPM6A, M6A. Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. Interacts with OPRM1 (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of GPM6A (PubMed:24705354).

EXTERNAL LINKS

GPM6A

Neuronal membrane glycoprotein M6-a

GPM6A

Molecular Synopsis