FEATURES

FAMILY

DESCRIPTION

Also known as EFNA3_HUMAN, EFNA3, EFL2, EPLG3, LERK3. Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Interacts with EPHA8; activates EPHA8.

Also known as EFNA3_HUMAN, EFNA3, EFL2, EPLG3, LERK3. Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesi ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EFNA3

Ephrin-A3

EFNA3

Molecular Synopsis