FEATURES

FAMILY

DESCRIPTION

Also known as THOP1_HUMAN, THOP1. Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

THOP1

Thimet oligopeptidase

THOP1

Molecular Synopsis