FEATURES

FAMILY

mitochondrial carrier (TC 2.A.29) family

DESCRIPTION

Also known as TXTP_HUMAN, SLC25A1, SLC20A3. Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate (PubMed:29031613, PubMed:29238895). Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extend cis-aconitate, maleate and succinate (PubMed:29031613). In the cytoplasm citrate is important in the regulation of glycolysis through a feedback mechanism and in the production of acetyl-CoA which is needed for the synthesis of fatty acids, sterols, prostaglandins, dolichol and coenzyme Q (CoQ). Required for proper neuromuscular junction formation (Probable).

EXTERNAL LINKS

SLC25A1

Tricarboxylate transport protein, mitochondrial

SLC25A1

Molecular Synopsis