FEATURES

FAMILY

DESCRIPTION

Also known as NRL_HUMAN, NRL, D14S46E. Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). Interacts with FIZ1; this interaction represses transactivation (By similarity). Interacts (via the leucine-zipper domain) with CRX (PubMed:10887186).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NRL

Neural retina-specific leucine zipper protein

NRL

Molecular Synopsis