FEATURES

FAMILY

DESCRIPTION

Also known as PSA_HUMAN, NPEPPS, PSA. Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NPEPPS

Puromycin-sensitive aminopeptidase

NPEPPS

Molecular Synopsis