FEATURES

FAMILY

DESCRIPTION

Also known as ARP19_HUMAN, ARPP19. Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ARPP19

cAMP-regulated phosphoprotein 19

ARPP19

Molecular Synopsis